Metformin Can Attenuate Beta-Cell Hypersecretion—Implications for Treatment of Children with Obesity

In children with obesity, insulin hypersecretion is proposed to precede resistance. We investigated if metformin could be used attenuate secretion from palmitate-treated isolated islets and its implication for obesity. Human were exposed palmitate 0.5 or 1 day, when was introduced. After culture, glucose-stimulated (GSIS) measured. Children who had received over six months (n = 21, age 13.9 ± 1.8), retrospectively evaluated. classified as either “reducing” “increasing” based on the difference between AUC0–120 of during OGTT before after treatment. human islets, GSIS increased culture in up day but declined continued exposure. Whereas adding exposure GSIS, days reduced GSIS. 9), 2 h glucose triglycerides decreased treatment, which not observed patients 12). attenuated introduced islet secretory capacity maintained. improved glycemic lipid levels accompanied by